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Target
Monocarboxylate transporter 4
Ligand
BDBM345262
Substrate
n/a
Meas. Tech.
MCT4-Mediated Lactate Transport in NCI-H358 Lung Adenocarcinoma Cells (Assay 2)
IC50
81.0±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US11724989 Publication Date 8/15/2023 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM345262
Synonyms:
2-[[1-[(2-Chlorophenyl)methyl]-5-phenyl- pyrazol-3-yl]methoxy]-2-methyl- propanoic acid 1H NMR (DMSO-d6, 400 MHz) $#948; 1.56 (s, 6H), 4.58 (s, 2H), 5.41 (s, 2H), 6.56 (s, 1H), 6.75-6.78 (m, 1H), 7.20-7.30 (m, 4H), 7.32-7.43 (m, 4H). 1H NMR (CD3OD, 400 MHz) $#948; 1.54 (s, 6H), 4.589s, 2H), 5.40 (s, 2H), 6.55 (s, 1H), 6.68-6.74 (m, 1H), 7.20-7.42 (m, 8H). | US10202350, Example 8 | US10214492, Example 8 | US11292767, Example 8 | US11724989, Example 8
Type:
Small organic molecule
Emp. Form.:
C21H21ClN2O3
Mol. Mass.:
384.856
SMILES:
CC(C)(OCc1cc(-c2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Structure:
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