Reaction Details Report a problem with these data
Target
Flavin reductase (NADPH)
Ligand
BDBM79514
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
Kd
160±30 nM
Citation
 Ryu, K; Kim, M; Griesinger, C; Lee, D Method of increasing platelet counts of a subject US Patent  US11744839 Publication Date 9/5/2023 
Target
Name:
Flavin reductase (NADPH)
Synonyms:
1.3.1.24 | 1.5.1.30 | BLVRB | BLVRB_HUMAN | BVR-B | Biliverdin reductase B | Biliverdin-IX beta-reductase | FLR
Type:
PROTEIN
Mol. Mass.:
22123.63
Organism:
Homo sapiens
Description:
ChEMBL_100283
Residue:
206
Sequence:
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ
  
Inhibitor
Name:
BDBM79514
Synonyms:
Erythrosin B | MLS001335987 | SMR000875321 | US11744839, Compound Erythrosin B | cid_25162930 | sodium;2-(2,4,5,7-tetraiodo-3-keto-6-oxido-xanthen-9-yl)benzoate | sodium;2-(2,4,5,7-tetraiodo-3-oxido-6-oxo-9-xanthenyl)benzoate | sodium;2-(2,4,5,7-tetraiodo-3-oxido-6-oxoxanthen-9-yl)benzoate | sodium;2-[2,4,5,7-tetrakis(iodanyl)-3-oxidanidyl-6-oxidanylidene-xanthen-9-yl]benzoate
Type:
Small organic molecule
Emp. Form.:
C20H6I4O5
Mol. Mass.:
833.8776
SMILES:
[O-]C(=O)c1ccccc1-c1c2cc(I)c([O-])c(I)c2oc2c(I)c(=O)c(I)cc12 |(5.85,4.65,;5.85,3.11,;4.52,2.34,;7.18,2.34,;7.18,3.88,;8.52,4.65,;9.85,3.88,;9.85,2.34,;8.52,1.57,;8.52,.03,;9.85,-.74,;11.23,.08,;12.62,-.71,;13.95,.06,;12.62,-2.32,;13.95,-3.09,;11.23,-3.11,;11.21,-4.65,;9.85,-2.28,;8.52,-3.05,;7.18,-2.28,;5.81,-3.11,;5.82,-4.65,;4.41,-2.32,;3.08,-3.09,;4.41,-.71,;3.08,.06,;5.81,.08,;7.18,-.74,)|
Structure:
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