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Target
Eukaryotic translation initiation factor 4E [28-217]
Ligand
BDBM617377
Substrate
n/a
Meas. Tech.
Human eIF4E/4G2 Binding Assay
IC50
<1000±n/a nM
Citation
 Vandeusen, CL; Walts, AE; Or, YS EIF4E inhibitors and uses thereof US Patent  US11753403 Publication Date 9/12/2023 
Target
Name:
Eukaryotic translation initiation factor 4E [28-217]
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22131.40
Organism:
Homo sapiens (Human)
Description:
aa 28-217
Residue:
190
Sequence:
VANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM617377
Synonyms:
US11753403, Compound I-281
Type:
Small organic molecule
Emp. Form.:
C22H16ClF3N2O2S2
Mol. Mass.:
496.953
SMILES:
CC(C)c1sc(Nc2c(sc3ccccc23)C(O)=O)nc1-c1ccc(Cl)c(c1)C(F)(F)F
Structure:
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