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Target
Interleukin-17F
Ligand
BDBM617540
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
1000±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617540
Synonyms:
US20230286943, Example 8
Type:
Small organic molecule
Emp. Form.:
C26H32N6O3
Mol. Mass.:
476.5707
SMILES:
C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(cn1)-c1ccc(=O)n(C)c1C |r,wU:1.0,wD:7.8,4.4,(3.45,5.9,;3.45,4.36,;4.78,3.59,;4.78,2.05,;3.45,1.28,;2.12,2.05,;2.12,3.59,;3.45,-.26,;4.78,-1.03,;4.78,-2.57,;3.45,-3.34,;6.12,-3.34,;7.52,-2.71,;8.55,-3.86,;7.78,-5.19,;6.28,-4.87,;5.13,-5.9,;2.12,-1.03,;2.12,-2.57,;.78,-.26,;-.55,-1.03,;-.55,-2.57,;-1.89,-3.34,;-3.22,-2.57,;-3.22,-1.03,;-1.89,-.26,;-4.55,-3.34,;-4.55,-4.88,;-5.89,-5.65,;-7.22,-4.88,;-8.55,-5.65,;-7.22,-3.34,;-8.55,-2.57,;-5.89,-2.57,;-5.89,-1.03,)|
Structure:
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