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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM293437
Substrate
n/a
Meas. Tech.
GSK3β Kinase Assay
EC50
>10000±n/a nM
Citation
 KC, SK; Mak, CC; Eastman, BW; Cao, J; Bollu, V; Mittapalli, GK; Chiruta, C ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF US Patent  US20230286945 Publication Date 9/14/2023 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM293437
Synonyms:
US10106527, Compound 23 | US10544128, Compound 23 | US11548872, Compound 23 | US20230286945, Compound 23 | US9951048, Compound 23
Type:
Small organic molecule
Emp. Form.:
C26H27N7O
Mol. Mass.:
453.5389
SMILES:
CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(c1)C1CC1
Structure:
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