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Target
B-cell lymphoma 6 protein
Ligand
BDBM618555
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
6.92±n/a nM
Citation
 Bellenie, BR; Cheung, KM; Davis, OA; Hoelder, S; Huckvale, R; Collie, G; Meniconi, M; Brennan, A; Lloyd, MG BCL6 INHIBITORS US Patent  US20230287003 Publication Date 9/14/2023 
Target
Name:
B-cell lymphoma 6 protein
Synonyms:
B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
Type:
PROTEIN
Mol. Mass.:
78866.89
Organism:
Homo sapiens
Description:
ChEMBL_117695
Residue:
706
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
  
Inhibitor
Name:
BDBM618555
Synonyms:
US20230287003, Example 11b
Type:
Small organic molecule
Emp. Form.:
C26H30ClN7O4
Mol. Mass.:
540.014
SMILES:
Cn1c2ncc(Nc3nc(ncc3Cl)N3C4COCC3CC(O)C4)cc2c2N[C@H](CCOc2c1=O)C1CC1 |r,THB:22:21:14:16.18.17|
Structure:
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