Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP [241-356]
Ligand
BDBM620168
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assays
Ki
55±n/a nM
Citation
 COSFORD, ND; HEIMANN, D; TERIETE, P; CHANDA, SK; PACHE, L; DE BACKER, LJ; BATA, N INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS US Patent  US20230295181 Publication Date 9/21/2023 
Target
Name:
E3 ubiquitin-protein ligase XIAP [241-356]
Synonyms:
API3 | BIR3 domain of X-linked inhibitor of apoptosis protein | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR3) | E3 ubiquitin-protein ligase XIAP BIR-3 | E3 ubiquitin-protein ligase XIAP BIR3 | IAP3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP | XIAP-BIR3 | XIAP_HUMAN | baculovirus IAP repeat 3 (BIR3) domain of XIAP
Type:
Protein Binding Domain
Mol. Mass.:
13276.62
Organism:
Homo sapiens (Human)
Description:
BIR3 of XIAP: RESIDUES 241-356.
Residue:
116
Sequence:
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
  
Inhibitor
Name:
BDBM620168
Synonyms:
US20230295181, Compound 81
Type:
Small organic molecule
Emp. Form.:
C27H36N4O4
Mol. Mass.:
480.5991
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CCOC2CC3(CC=CC3)C(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 |r,c:15|
Structure:
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