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Target
fMet-Leu-Phe receptor
Ligand
BDBM620560
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
0.500±n/a nM
Citation
 Shirude, PS; Rachamreddy, CR; Baligar, V; Seshadri, B; Madduri, SR; Kick, EK; Wurtz, NR OXOPYRROLIDINE UREA FPR2 AGONISTS US Patent  US20230303513 Publication Date 9/28/2023 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM620560
Synonyms:
US20230303513, Example 8
Type:
Small organic molecule
Emp. Form.:
C29H29ClF2N4O5
Mol. Mass.:
587.014
SMILES:
COc1cc(F)c([C@@H]2CN(C(=O)[C@H]2NC(=O)NC2CCc3cc(Cl)ccc3C2)c2c(OC)ccn(C)c2=O)c(F)c1 |r,w:16.17|
Structure:
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