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Target
fMet-Leu-Phe receptor
Ligand
BDBM620642
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
0.300±n/a nM
Citation
 Shirude, PS; Rachamreddy, CR; Baligar, V; Seshadri, B; Madduri, SR; Kick, EK; Wurtz, NR OXOPYRROLIDINE UREA FPR2 AGONISTS US Patent  US20230303513 Publication Date 9/28/2023 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM620642
Synonyms:
US20230303513, Example 83 | US20230303513, Example 84
Type:
Small organic molecule
Emp. Form.:
C31H34F2N4O6
Mol. Mass.:
596.6217
SMILES:
COc1ccc2CC(CCc2c1)NC(=O)N[C@H]1[C@@H](CN(C1=O)c1c(C)ccn(CCO)c1=O)c1c(F)cc(OC)cc1F |r|
Structure:
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