Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM212586
Substrate
n/a
Meas. Tech.
Inhibitory Activity Against Human Renin
IC50
3.00±n/a nM
Citation
 Iijima, T; Sugama, H; Kawaguchi, T; Shen, J; Xia, G; Xie, J; Hirai, M Nitrogen-containing saturated heterocyclic compound US Patent  US10155731 Publication Date 12/18/2018 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM212586
Synonyms:
US10155731, Example 286 | US9278944, 286
Type:
Small organic molecule
Emp. Form.:
C22H34N4O4
Mol. Mass.:
418.5298
SMILES:
CCc1cc(cc(CCCNC(=O)OC)n1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1 |r|
Structure:
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