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Target
Activin receptor type-1
Ligand
BDBM621072
Substrate
n/a
Meas. Tech.
In Vitro Enzymatic Activity Inhibition Test (TGFbetaR1)
IC50
4.82±0.51 nM
Citation
 TIAN, Q; ZHANG, Y; JIANG, X; LIU, C; KANG, B; LIU, R; SONG, H; XUE, T; WANG, J PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF US Patent  US20230303562 Publication Date 9/28/2023 
Target
Name:
Activin receptor type-1
Synonyms:
2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I
Type:
n/a
Mol. Mass.:
57158.32
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
509
Sequence:
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM621072
Synonyms:
US20230303562, Example 10
Type:
Small organic molecule
Emp. Form.:
C16H13N7O
Mol. Mass.:
319.3207
SMILES:
Cc1cccc(n1)-n1nccc1-c1ccc2nnc(C(N)=O)n2c1
Structure:
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