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Target
Receptor-type tyrosine-protein kinase FLT3 [N841I]
Ligand
BDBM621126
Substrate
n/a
Meas. Tech.
Kinase Binding Assay
Kd
0.150±n/a nM
Citation
 HOYT, SB; THOMAS, CJ; FINOCCHIO, CJ; STARCZYNOWSKI, DT; TAWA, GJ; GRACIA MALDONADO, G; ROSEBAUM, JS MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF US Patent  US20230303563 Publication Date 9/28/2023 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [N841I]
Synonyms:
CD135 | FLK2 | FLT3 | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 (N841I) | STK1 | Tyrosine Kinase FLT3 Mutant (N841I)
Type:
Tyrosine-protein kinase
Mol. Mass.:
112887.67
Organism:
Homo sapiens (Human)
Description:
gi_121114304
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSIYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM621126
Synonyms:
6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)-N-((3R,4S)-4- (trifluoromethyl)pyrrolidin-3- yl)pyridin-2-amine | US20230303563, Compound 175
Type:
Small organic molecule
Emp. Form.:
C18H16F5N5
Mol. Mass.:
397.3452
SMILES:
FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4C(F)(F)F)n3)n2c1 |r|
Structure:
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