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Target
Presequence protease, mitochondrial
Ligand
BDBM622240
Substrate
n/a
Meas. Tech.
hPrep Inhibition Assay
IC50
130±n/a nM
Citation
 BRÅNALT, J; HOLM, B; JOHANSSON, M; KARLSSON, O; KNERR, DL; NORDQVIST, A; SHEPPARD, RJ; SWANSON, M; TOMBERG, A N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES US Patent  US20230312550 Publication Date 10/5/2023 
Target
Name:
Presequence protease, mitochondrial
Synonyms:
KIAA1104 | MP1 | Metalloprotease 1 | PITRM1 | PREP | PREP_HUMAN | Pitrilysin metalloproteinase 1 | hMP1 | hPreP
Type:
PROTEIN
Mol. Mass.:
117419.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108043
Residue:
1037
Sequence:
MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ
  
Inhibitor
Name:
BDBM622240
Synonyms:
US20230312550, Example 200
Type:
Small organic molecule
Emp. Form.:
C23H25N5O2S
Mol. Mass.:
435.542
SMILES:
O=C(CNC(=O)c1ccnc2ccc(cc12)N1CCC[C@H]1C1CC1)N1CSC[C@H]1C#N |r|
Structure:
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