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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM622545
Substrate
n/a
Meas. Tech.
PLK1 Inhibition Assay
Ki
>4000±n/a nM
Citation
LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P PTERIDINONE COMPOUNDS AND USES THEREOF US Patent US20230312587 Publication Date 10/5/2023
More Info.:
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
Inhibitor
Name:
BDBM622545
Synonyms:
(7S)-2-(((1-(3,5-difluoro-4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)amino)-5,8-diethyl-7-(2-hydroxyethyl)-7,8-dihydropteridin-6(5H)-one | US20230312587, Compound 48
Type:
Small organic molecule
Emp. Form.:
C24H29F2N7O3
Mol. Mass.:
501.529
SMILES:
CCN1[C@@H](CCO)C(=O)N(CC)c2cnc(NCc3cnn(Cc4cc(F)c(OC)c(F)c4)c3)nc12