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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM622554
Substrate
n/a
Meas. Tech.
PLK1 Inhibition Assay
Ki
>4000±n/a nM
Citation
 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P PTERIDINONE COMPOUNDS AND USES THEREOF US Patent  US20230312587 Publication Date 10/5/2023 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM622554
Synonyms:
(7S)-4,7,8-trimethyl-2-(((1-((1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one | US20230312587, Compound 160
Type:
Small organic molecule
Emp. Form.:
C19H22F3N9O
Mol. Mass.:
449.4329
SMILES:
C[C@@H]1N(C)c2nc(NCc3cnn(Cc4cc(nn4C)C(F)(F)F)c3)nc(C)c2NC1=O
Structure:
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