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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM622556
Substrate
n/a
Meas. Tech.
PLK1 Inhibition Assay
Ki
>4000±n/a nM
Citation
 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P PTERIDINONE COMPOUNDS AND USES THEREOF US Patent  US20230312587 Publication Date 10/5/2023 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM622556
Synonyms:
2′-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-4′,8′-dimethyl-5′,8′-dihydro-6′H-spiro[cyclopropane-1,7′-pteridin]-6′-on | US20230312587, Compound 221
Type:
Small organic molecule
Emp. Form.:
C21H22FN7O
Mol. Mass.:
407.4441
SMILES:
CN1c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)nc(C)c2NC(=O)C11CC1
Structure:
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