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Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Ligand
BDBM622886
Substrate
n/a
Meas. Tech.
Human ACMSD-1 Inhibitor Assay
IC50
4.00±n/a nM
Citation
 Takahashi, T; Ji, N Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors US Patent  US11780812 Publication Date 10/10/2023 
Target
Name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms:
ACMSD | ACMSD_HUMAN | Picolinate carboxylase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38037.38
Organism:
Homo sapiens (Human)
Description:
Q8TDX5
Residue:
336
Sequence:
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
  
Inhibitor
Name:
BDBM622886
Synonyms:
US11780812, Ex. 40
Type:
Small organic molecule
Emp. Form.:
C9H4ClF3N6OS
Mol. Mass.:
336.681
SMILES:
FC(F)(F)c1c(Cl)c(=O)[nH]c(SCc2nnn[nH]2)c1C#N
Structure:
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