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Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Ligand
BDBM622887
Substrate
n/a
Meas. Tech.
Human ACMSD-1 Inhibitor Assay
IC50
3.00±n/a nM
Citation
 Takahashi, T; Ji, N Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors US Patent  US11780812 Publication Date 10/10/2023 
Target
Name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms:
ACMSD | ACMSD_HUMAN | Picolinate carboxylase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38037.38
Organism:
Homo sapiens (Human)
Description:
Q8TDX5
Residue:
336
Sequence:
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
  
Inhibitor
Name:
BDBM622887
Synonyms:
US11780812, Ex. 41
Type:
Small organic molecule
Emp. Form.:
C20H13ClN2O3S
Mol. Mass.:
396.847
SMILES:
OC(=O)c1cccc(CSc2[nH]c(=O)c(Cl)c(-c3ccccc3)c2C#N)c1
Structure:
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