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Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Ligand
BDBM622901
Substrate
n/a
Meas. Tech.
Human ACMSD-1 Inhibitor Assay
IC50
3.00±n/a nM
Citation
 Takahashi, T; Ji, N Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors US Patent  US11780812 Publication Date 10/10/2023 
Target
Name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms:
ACMSD | ACMSD_HUMAN | Picolinate carboxylase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38037.38
Organism:
Homo sapiens (Human)
Description:
Q8TDX5
Residue:
336
Sequence:
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
  
Inhibitor
Name:
BDBM622901
Synonyms:
US11780812, Ex. 55
Type:
Small organic molecule
Emp. Form.:
C21H16N6OS
Mol. Mass.:
400.456
SMILES:
Cc1cccc(c1)-c1cc(=O)[nH]c(SCc2cccc(c2)-c2nnn[nH]2)c1C#N
Structure:
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