Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 2
Ligand
BDBM624078
Substrate
n/a
Meas. Tech.
FGFR2 Biochemical Caliper Assay
IC50
<100±n/a nM
Citation
 Touré, B; Schoenherr, H; Giordanetto, F; Moustakas, DT; Hudson, BM FGFR inhibitors and methods of use thereof US Patent  US11780845 Publication Date 10/10/2023 
Target
Name:
Fibroblast growth factor receptor 2
Synonyms:
BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2
Type:
Enzyme
Mol. Mass.:
92015.45
Organism:
Homo sapiens (Human)
Description:
P21802
Residue:
821
Sequence:
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
  
Inhibitor
Name:
BDBM624078
Synonyms:
US11780845, Example 1098
Type:
Small organic molecule
Emp. Form.:
C26H24N8O2
Mol. Mass.:
480.5212
SMILES:
Cc1cccc(Oc2ccc(cc2)-c2c(-c3cc(NC(=O)C=C)nn3C)n(C)c3ncnc(N)c23)n1 |(2.87,6.69,;2.4,5.23,;3.43,4.08,;2.95,2.62,;1.45,2.3,;.42,3.44,;-1.09,3.12,;-1.57,1.66,;-.54,.51,;-1.01,-.95,;-2.52,-1.27,;-3.55,-.13,;-3.07,1.34,;-2.99,-2.74,;-2.09,-3.98,;-.55,-3.98,;.36,-2.74,;1.82,-3.21,;3.07,-2.31,;4.47,-2.93,;4.63,-4.46,;5.72,-2.03,;7.13,-2.65,;1.82,-4.75,;.36,-5.23,;-.12,-6.69,;-2.99,-5.23,;-2.52,-6.69,;-4.46,-4.75,;-5.79,-5.52,;-7.13,-4.75,;-7.13,-3.21,;-5.79,-2.44,;-5.79,-.9,;-4.46,-3.21,;.89,4.91,)|
Structure:
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