Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM311102
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
14.0±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Amidoethyl azole orexin receptor antagonists US Patent  US10155750 Publication Date 12/18/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM311102
Synonyms:
2-cyclopropyl-N- ethyl-N-(2-(4-(2- hydroxypropan-2-yl)- 5-methyl-2H-1,2,3- triazol-2-yl)ethyl)-6- methoxynicotinamide | US10155750, Example 39
Type:
Small organic molecule
Emp. Form.:
C20H29N5O3
Mol. Mass.:
387.476
SMILES:
CCN(CCn1nc(C)c(n1)C(C)(C)O)C(=O)c1ccc(OC)nc1C1CC1
Structure:
Search PDB for entries with ligand similarity: