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Target
Alpha-2B adrenergic receptor
Ligand
BDBM626100
Substrate
n/a
Meas. Tech.
SPR Assay
IC50
25560±n/a nM
Citation
 Bell, AS; Schreyer, AM; Versluys, S Pyrazolopyrimidine compounds as adenosine receptor antagonists US Patent  US11786528 Publication Date 10/17/2023 
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR
Type:
Enzyme
Mol. Mass.:
49964.20
Organism:
Homo sapiens (Human)
Description:
P18089
Residue:
450
Sequence:
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
  
Inhibitor
Name:
BDBM626100
Synonyms:
US11786528, Example 24
Type:
Small organic molecule
Emp. Form.:
C17H13F3N6S
Mol. Mass.:
390.386
SMILES:
Cc1ccc(Cn2cc3c(N)nc(nc3n2)-c2ccsn2)cc1C(F)(F)F
Structure:
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