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Target
Prostaglandin G/H synthase 2
Ligand
BDBM13066
Substrate
n/a
Meas. Tech.
Enzyme (COXs) Inhibition Assay
IC50
20.0±1 nM
Citation
 Kandeel, M; Burayk, S Methods of inhibiting cyclooxygenase US Patent  US11786535 Publication Date 10/17/2023 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
COX2 | Cyclooxygenase-2 (COX-2) | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (PGHS-2)(FLAG-Native)
Type:
Enzyme
Mol. Mass.:
69995.82
Organism:
Homo sapiens (Human)
Description:
P35354; containing a FLAG tag at the N terminus
Residue:
612
Sequence:
DYKDDDDKMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM13066
Synonyms:
2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid | CHEMBL139 | Diclofenac | US11337935, Compound Diclofenac | US11478464, Compound Diclofenac | US11786535, Compound Diclofenac | {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
Type:
Small organic molecule
Emp. Form.:
C14H11Cl2NO2
Mol. Mass.:
296.149
SMILES:
OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Structure:
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