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Target
Transcriptional enhancer factor TEF-3
Ligand
BDBM626354
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
50.0±n/a nM
Citation
 Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent  US11787775 Publication Date 10/17/2023 
Target
Name:
Transcriptional enhancer factor TEF-3
Synonyms:
RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3
Type:
PROTEIN
Mol. Mass.:
48333.01
Organism:
Homo sapiens
Description:
ChEMBL_118073
Residue:
434
Sequence:
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
  
Inhibitor
Name:
BDBM626354
Synonyms:
2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluoromethoxy)phenyl]-3H- benzofuran-5-yl]amino]methyl]prop- 2-enehydroxamic acid | US11787775, Compound 37 | US11787775, Compound 39
Type:
Small organic molecule
Emp. Form.:
C20H16F3N3O4
Mol. Mass.:
419.3539
SMILES:
ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1
Structure:
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