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Target
D-amino-acid oxidase
Ligand
BDBM627551
Substrate
n/a
Meas. Tech.
In Vitro Measurements of Human D-Amino Acid Oxidase (hDAAO) Activity Assay
IC50
2.40±n/a nM
Citation
 Tsai, GE; Mao, Y; Lu, L; Chang, W; Hsieh, H; Hu, JW; Shih, T; Huang, C Compounds and pharmaceutical uses thereof US Patent  US11793823 Publication Date 10/24/2023 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM627551
Synonyms:
US11793823, Compound 123
Type:
Small organic molecule
Emp. Form.:
C145H90O85
Mol. Mass.:
3192.2151
SMILES:
Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)O[C@@H]1CO[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(OC(=O)c6cc(O)c(O)c(O)c6)c5)c4)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(OC(=O)c6cc(O)c(O)c(O)c6)c5)c4)c3)c2)[C@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(O)c5)c4)c3)c2)c1 |r|
Structure:
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