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Target
Lanosterol 14-alpha demethylase
Ligand
BDBM628861
Substrate
n/a
Meas. Tech.
Inhibition of CYP51A1
IC50
<100±n/a nM
Citation
 WRONA, I; OZBOYA, K; LE BOURDONNEC, B; KURIA, V; MACDONNELL, M; LUCAS, M; DELABARRE, B AMINO ALCOHOL COMPOUNDS AND USES THEREOF US Patent  US20230339890 Publication Date 10/26/2023 
Target
Name:
Lanosterol 14-alpha demethylase
Synonyms:
CP51A_HUMAN | CYP51 | CYP51A1 | CYPLI | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase
Type:
Protein
Mol. Mass.:
56817.21
Organism:
Homo sapiens (Human)
Description:
Q16850
Residue:
509
Sequence:
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
  
Inhibitor
Name:
BDBM628861
Synonyms:
US20230339890, Compound 144
Type:
Small organic molecule
Emp. Form.:
C24H31F3N4O4
Mol. Mass.:
496.5225
SMILES:
CC(C)(C)OC(=O)NCCCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(nc1)C(F)(F)F
Structure:
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