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Target
Casein kinase I isoform alpha
Ligand
BDBM629286
Substrate
n/a
Meas. Tech.
CSNK1A1 Inhibitory activity Assay 2
IC50
1.69±n/a nM
Citation
 Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Christian, S; Bömer, U; Hillig, null; Lechner, C; Mortier, JX; Kaulfuss, S; Corsello, S; Handing, K; Madec, A; Furst, L; Shekhar, M; Berger, M; Rupaimoole, R; Lienau, P; Orsi, D; McKinney, D; Brezezinka, K SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF US Patent  US20230339939 Publication Date 10/26/2023 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM629286
Synonyms:
(+)-N-{4-[5-fluoro-3-(5-fluoropyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-2-(4-fluorophenyl)propanamide (Enantiomer 1) | US20230339939, Example 48
Type:
Small organic molecule
Emp. Form.:
C26H18F3N5O
Mol. Mass.:
473.4492
SMILES:
CC(C(=O)Nc1cc(ccn1)-c1[nH]c2ccc(F)nc2c1-c1ccc(F)cn1)c1ccc(F)cc1
Structure:
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