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Target
fMet-Leu-Phe receptor
Ligand
BDBM632025
Substrate
n/a
Meas. Tech.
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays
EC50
0.600±n/a nM
Citation
 Shirude, PS; Rachamreddy, CR; Chattopadhyay, AK; Seshadri, B; Baligar, V; Madduri, SR; Kick, EK; Wurtz, NR OXOPYRROLIDINE FPR2 AGONISTS US Patent  US20230348426 Publication Date 11/2/2023 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM632025
Synonyms:
US20230348426, Example 295
Type:
Small organic molecule
Emp. Form.:
C31H34F2N4O7
Mol. Mass.:
612.6211
SMILES:
COCC(C(=O)N(C)C)n1ccc(C)c(N2C[C@H]([C@H](NC(=O)c3ccc(OC(F)F)cc3)C2=O)c2ccc(OC)cc2)c1=O |w:3.2|
Structure:
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