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Target
fMet-Leu-Phe receptor
Ligand
BDBM632189
Substrate
n/a
Meas. Tech.
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays
EC50
0.300±n/a nM
Citation
 Shirude, PS; Rachamreddy, CR; Chattopadhyay, AK; Seshadri, B; Baligar, V; Madduri, SR; Kick, EK; Wurtz, NR OXOPYRROLIDINE FPR2 AGONISTS US Patent  US20230348426 Publication Date 11/2/2023 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM632189
Synonyms:
US20230348426, Example 459 | US20230348426, Example 610
Type:
Small organic molecule
Emp. Form.:
C29H29F2N3O5
Mol. Mass.:
537.5545
SMILES:
COc1ccc(cc1)[C@@H]1CN(C(=O)[C@H]1NC(=O)c1ccc(OC(F)F)cc1)c1c(C)ccn(CC2CC2)c1=O
Structure:
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