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Target
Galectin-1
Ligand
BDBM632596
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
354±n/a nM
Citation
 BOLLI, M; GATFIELD, J; GRISOSTOMI, C; REMEN, L; SAGER, C; ZUMBRUNN, C GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES US Patent  US20230348442 Publication Date 11/2/2023 
Target
Name:
Galectin-1
Synonyms:
14 kDa lectin | Galaptin | HPL | LEG1_HUMAN | LGALS1 | Lactose-binding lectin 1 | Lectin galactoside-binding soluble 1 | Putative MAPK-activating protein PM12
Type:
beta galactoside-binding protein
Mol. Mass.:
14713.53
Organism:
Homo sapiens (Human)
Description:
P09382
Residue:
135
Sequence:
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
  
Inhibitor
Name:
BDBM632596
Synonyms:
(2R,3R,4S,5R,6R)-N-(3-bromo-5-cyanophenyl)-4-(4-(3,4-dichlorophenyl)-1H- 1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2-hydroxycyclobutyl)-6- (hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-carboxamide | US20230348442, Example 2.8.5
Type:
Small organic molecule
Emp. Form.:
C27H26BrCl2N5O6
Mol. Mass.:
667.335
SMILES:
CO[C@H]1[C@@H](O[C@H](CO)[C@H](O)[C@@H]1n1cc(nn1)-c1ccc(Cl)c(Cl)c1)C(=O)N([C@H]1CC[C@@H]1O)c1cc(Br)cc(c1)C#N
Structure:
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