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Target
Serine/threonine-protein kinase SIK2
Ligand
BDBM632968
Substrate
n/a
Meas. Tech.
Inhibition of SIK; Abl and Src Kinases by Other Kinase Inhibitor
IC50
<10.00±n/a nM
Citation
 SENNHENN, P; BISSINGER, S; LOFERER, H; BANCROFT, D; MICHELS, T; KHANDELWAL, N HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF US Patent  US20230348453 Publication Date 11/2/2023 
Target
Name:
Serine/threonine-protein kinase SIK2
Synonyms:
KIAA0781 | QIK | SIK2 | SIK2_HUMAN | SNF1LK2 | Salt-inducible kinase 2 (SIK2) | Serine/threonine-protein kinase SIK2
Type:
Protein
Mol. Mass.:
103906.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
926
Sequence:
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN
  
Inhibitor
Name:
BDBM632968
Synonyms:
N-(2-chloro-4-(fluoromethyl)thiophen- 3-yl)-2-((6-(4-(2- hydroxyethyl)piperazin-1-yl)-2- methylpyrimidin-4-yl)amino)thiazole-5- carboxamide | US20230348453, Compound E3
Type:
Small organic molecule
Emp. Form.:
C20H23ClFN7O2S2
Mol. Mass.:
512.024
SMILES:
Cc1nc(Nc2ncc(s2)C(=O)Nc2c(CF)csc2Cl)cc(n1)N1CCN(CCO)CC1
Structure:
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