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Target
Myelin transcription factor 1
Ligand
BDBM633070
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
5.00±n/a nM
Citation
 SZYCHOWSKI, J; LIU, B; DIETRICH, E; PERRYMAN, A; CRANE, SN; TRUONG, VL; ABDOLI, A; BOUCHARD, A QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME US Patent  US20230348456 Publication Date 11/2/2023 
Target
Name:
Myelin transcription factor 1
Synonyms:
KIAA0835 | KIAA1050 | MTF1 | MYT1 | MYT1_HUMAN | MYTI | Myelin transcription factor I | PLPB1
Type:
PROTEIN
Mol. Mass.:
122258.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942118
Residue:
1121
Sequence:
MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV
  
Inhibitor
Name:
BDBM633070
Synonyms:
US20230348456, Compound 91
Type:
Small organic molecule
Emp. Form.:
C25H19N7O3
Mol. Mass.:
465.4635
SMILES:
Cc1ccc2[nH]ncc2c1-c1cc(-c2cccc(OCc3ncco3)n2)c2nc[nH]c(=O)c2c1N |(-.52,6.01,;.82,5.24,;2.15,6.01,;3.48,5.24,;3.48,3.7,;4.63,2.67,;4,1.27,;2.47,1.43,;2.15,2.93,;.82,3.7,;-.52,2.93,;-.52,1.39,;-1.85,.62,;-1.85,-.92,;-3.19,-1.69,;-3.19,-3.23,;-1.85,-4,;-.52,-3.23,;.82,-4,;2.15,-3.23,;3.48,-4,;3.48,-5.54,;4.95,-6.01,;5.85,-4.77,;4.95,-3.52,;-.52,-1.69,;-3.19,1.39,;-4.52,.62,;-5.85,1.39,;-5.85,2.93,;-4.52,3.7,;-4.52,5.24,;-3.19,2.93,;-1.85,3.7,;-1.85,5.24,)|
Structure:
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