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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM633161
Substrate
n/a
Meas. Tech.
Determination of Allosteric Inhibition Activities of the Compounds of the Present Invention on SHP2
IC50
1.000±n/a nM
Citation
 Huang, X; Guo, Y; Qiu, Z; Bie, P; Liao, W; Yan, Q; Shen, W; Cao, H; Xing, Q; Wang, X; Cao, Q; Meng, L; Wu, N; Li, W; Ye, C; Hu, T; Chen, L Heteroaryl Derivative, Preparation Method Therefor, And Use Thereof US Patent  US20230348467 Publication Date 11/2/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM633161
Synonyms:
US20230348467, Compound 9
Type:
Small organic molecule
Emp. Form.:
C25H22Cl2N6O2
Mol. Mass.:
509.387
SMILES:
N[C@@H]1c2ccccc2CC11CCN(CC1)c1nc(C(O)=O)c2c(n[nH]c2n1)-c1cccc(Cl)c1Cl
Structure:
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