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Target
Glycogen [starch] synthase, muscle
Ligand
BDBM634954
Substrate
n/a
Meas. Tech.
Kinetic Biochemical Assay
IC50
4.00±n/a nM
Citation
 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof US Patent  US11814367 Publication Date 11/14/2023 
Target
Name:
Glycogen [starch] synthase, muscle
Synonyms:
GYS | GYS1 | GYS1_HUMAN | Glycogen [starch] synthase, muscle | Glycogen synthase (GYS1) | Muscle glycogen synthase
Type:
Enzyme
Mol. Mass.:
83779.52
Organism:
Homo sapiens (Human)
Description:
P13807
Residue:
737
Sequence:
MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN
  
Inhibitor
Name:
BDBM634954
Synonyms:
US11814367, Compound 403
Type:
Small organic molecule
Emp. Form.:
C25H25F5N6O2
Mol. Mass.:
536.497
SMILES:
CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1[nH]nnc1C(F)(F)F)c1ccccc1 |r|
Structure:
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