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Target
Diacylglycerol kinase alpha
Ligand
BDBM641916
Substrate
n/a
Meas. Tech.
DGKα Biochemical Activity Assay
IC50
3.90±n/a nM
Citation
 Sawa, M; Arai, M; Nakai, R; Matsumoto, H; Pugh, C; Hu, E; Guerrero, J; Jacobsen, J; Medley, JW; Xu, J; Lad, L; Patel, L; Graupe, M; Zhu, Q; Holmbo, S; Kobayashi, T; Watkins, W; Moazami, Y; Yeung, SC; Codelli, JA; Weaver, HA Diacylglycerol kinase modulating compounds US Patent  US11845723 Publication Date 12/19/2023 
Target
Name:
Diacylglycerol kinase alpha
Synonyms:
2.7.1.107 | 80 kDa diacylglycerol kinase | DAG kinase alpha | DAGK | DAGK1 | DGK-alpha | DGKA | DGKA_HUMAN | Diacylglycerol kinase alpha | Diglyceride kinase alpha
Type:
PROTEIN
Mol. Mass.:
82631.86
Organism:
Homo sapiens
Description:
ChEMBL_117392
Residue:
735
Sequence:
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRSTNFFGFLS
  
Inhibitor
Name:
BDBM641916
Synonyms:
US11845723, Example 818
Type:
Small organic molecule
Emp. Form.:
C24H21ClFN5
Mol. Mass.:
433.908
SMILES:
CN(c1cc(F)cc(c1)C#CC(C)(C)C1CC1)c1nc2nncn2c2cc(Cl)ccc12
Structure:
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