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Target
Arginase-1
Ligand
BDBM642208
Substrate
n/a
Meas. Tech.
Inhibition of Arginase
IC50
9.40±n/a nM
Citation
 Kurhade, S; Dömling, A Arginase inhibitors US Patent  US11845767 Publication Date 12/19/2023 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM642208
Synonyms:
(5-amino-5-(1-(2-((2-fluorobenzyl)amino)- 2-oxoethyl)-1H-tetrazol-5- yl)pentyl)boronic acid | US11845767, Example 253
Type:
Small organic molecule
Emp. Form.:
C15H22BFN6O3
Mol. Mass.:
364.183
SMILES:
NC(CCCCB(O)O)c1nnnn1CC(=O)NCc1ccccc1F
Structure:
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