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Target
Arginase-1
Ligand
BDBM642280
Substrate
n/a
Meas. Tech.
Inhibition of Arginase
IC50
7.80±n/a nM
Citation
 Kurhade, S; Dömling, A Arginase inhibitors US Patent  US11845767 Publication Date 12/19/2023 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM642280
Synonyms:
(6-amino-6-(1-(2-((4- chlorobenzyl)amino)-2-oxoethyl)-1H- tetrazol-5-yl)hexyl)boronic acid | US11845767, Example 325
Type:
Small organic molecule
Emp. Form.:
C16H24BClN6O3
Mol. Mass.:
394.664
SMILES:
NC(CCCCCB(O)O)c1nnnn1CC(=O)NCc1ccc(Cl)cc1
Structure:
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