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Target
Arginase-2, mitochondrial
Ligand
BDBM642309
Substrate
n/a
Meas. Tech.
Inhibition of Arginase
IC50
30.0±n/a nM
Citation
 Kurhade, S; Dömling, A Arginase inhibitors US Patent  US11845767 Publication Date 12/19/2023 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM642309
Synonyms:
(+)-(R)-(5-amino-5-(1-(2-oxo-2-(prop-2- yn-1-ylamino)ethyl)-1H-tetrazol-5- yl)pentyl)boronic acid | US11845767, Example 355
Type:
Small organic molecule
Emp. Form.:
C11H19BN6O3
Mol. Mass.:
294.118
SMILES:
N[C@H](CCCCB(O)O)c1nnnn1CC(=O)NCC#C
Structure:
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