Target
Arginase-1
Ligand
BDBM642315
Substrate
n/a
Meas. Tech.
Inhibition of Arginase
IC50
10.5±n/a nM
Citation
 Kurhade, SDömling, A Arginase inhibitors US Patent  US11845767 Publication Date 12/19/2023 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM642315
Synonyms:
(+)-(R)-(5-amino-5-(1-(2-oxo-2- (phenethylamino)ethyl)-1H-tetrazol-5- yl)pentyl)boronic acid | SHK277 | US11845767, Example 361
Type:
Small organic molecule
Emp. Form.:
C16H25BN6O3
Mol. Mass.:
360.219
SMILES:
N[C@H](CCCCB(O)O)c1nnnn1CC(=O)NCCc1ccccc1
Structure:
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