Target
Cyclin-A2/Cyclin-dependent kinase 2
Ligand
BDBM642757
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
1.000±n/a nM
Citation
 Cheng, HXiong, WNiu, WYu, BJiang, Y HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS US Patent  US20230416271 Publication Date 12/28/2023 
Target
Name:
Cyclin-A2/Cyclin-dependent kinase 2
Synonyms:
CDK2-CyclinA | CDK2/A | CDK2/Cyclin A | CDK2/Cyclin A2 | Cyclin A2/dependent kinase 2 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-Dependent Kinase 2 (CDK2A)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
Cdk2/Cyclin A kinase was purified from insect cells coinfected with Cyclin A/Cdk2 baculovirus.
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
Cyclin-A2
Synonyms:
CCN1 | CCNA | CCNA1 | CCNA2 | CCNA2_HUMAN | Cyclin A | Cyclin-A
Type:
Enzyme Subunit
Mol. Mass.:
48550.19
Organism:
Homo sapiens (Human)
Description:
P20248
Residue:
432
Sequence:
MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
  
Inhibitor
Name:
BDBM642757
Synonyms:
N-(4-((1-isopropyl-1H-[1,2,3]triazolo[4,5-h]quinazolin-8- yl)amino)cyclohexyl)methanesulfonamide | US20230416271, Compound II.11
Type:
Small organic molecule
Emp. Form.:
C18H25N7O2S
Mol. Mass.:
403.502
SMILES:
CC(C)n1nnc2ccc3cnc(NC4CC[C@@H](CC4)NS(C)(=O)=O)nc3c12 |r,wU:17.20,(-3.87,-.93,;-5.35,-.5,;-6.46,-1.57,;-5.71,1,;-7.14,1.58,;-7.03,3.11,;-5.53,3.48,;-4.8,4.84,;-3.26,4.89,;-2.45,3.58,;-.91,3.63,;-.1,2.32,;-.83,.96,;-.02,-.35,;1.52,-.3,;2.33,-1.61,;3.87,-1.56,;4.6,-.21,;3.79,1.1,;2.25,1.06,;6.14,-.16,;6.95,-1.47,;5.64,-2.28,;7.76,-2.78,;8.26,-.66,;-2.37,.91,;-3.18,2.22,;-4.72,2.17,)|
Structure:
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