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Target
Monoacylglycerol lipase ABHD6 [33-337]
Ligand
BDBM645019
Substrate
n/a
Meas. Tech.
Evaluation of ABHD6 Enzyme Inhibitory Activity Assay
IC50
2.00±n/a nM
Citation
 YOSHIDA, A; HYAKUTAKE, R; NAGASHIMA, N; MISU, R; MORI, S ABHD6 ANTAGONIST US Patent  US20240010658 Publication Date 1/11/2024 
Target
Name:
Monoacylglycerol lipase ABHD6 [33-337]
Synonyms:
Monoacylglycerol lipase ABHD6 (33-337)
Type:
Enzyme
Mol. Mass.:
34939.75
Organism:
Homo sapiens (Human)
Description:
Q9BV23[33-337]
Residue:
305
Sequence:
ALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
  
Inhibitor
Name:
BDBM645019
Synonyms:
US20240010658, Example 2-14
Type:
Small organic molecule
Emp. Form.:
C20H27BrN4O
Mol. Mass.:
419.359
SMILES:
Brc1ccc(N[C@@H]2CC[C@H]3CN(C[C@@H]23)C(=O)C2CC3CCC2CC3)nn1 |r,wU:9.9,13.12,wD:6.5,(8.14,-1.27,;6.68,-.8,;6.36,.71,;4.89,1.18,;3.75,.15,;2.28,.63,;1.14,-.4,;1.3,-1.93,;-.11,-2.56,;-1.14,-1.41,;-2.65,-1.09,;-2.81,.44,;-1.4,1.06,;-.37,-.08,;-4.14,1.21,;-4.14,2.75,;-5.47,.44,;-6.81,1.21,;-8.14,.44,;-8.14,-1.1,;-6.81,-1.87,;-5.47,-1.1,;-6.28,.19,;-7.37,-.9,;4.07,-1.35,;5.53,-1.83,)|
Structure:
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