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Target
Dimer of Gag-Pol polyprotein [489-587]
Ligand
BDBM3401
Substrate
Chromogenic Peptide Substrate
Meas. Tech.
Protease Inhibition Assay
pH
5.6±n/a
Temperature
310.15±n/a K
Ki
20000±4400 nM
Citation
Melnick, M; Reich, SH; Lewis, KK; Mitchell, LJ; Nguyen, D; Trippe, AJ; Dawson, H; Davies, JF; Appelt, K; Wu, BW; Musick, L; Gehlhaar, DK; Webber, S; Shetty, B; Kosa, M; Kahil, D; Andrada, D Bis tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design. J Med Chem 39:2795-811 (1996) [PubMed] Article
More Info.:
Target
Name:
Dimer of Gag-Pol polyprotein [489-587]
Synonyms:
HIV-1 Protease
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10822.21
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Component 2
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10822.21
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM3401
Synonyms:
2-Butanol deriv. 8 | 2-[4-[2-(tert-Butylcarbamoyl)phenyl]-2-hydroxybutyl]-benzoic Acid tert-Butyl Amide | AG1132 | N-tert-butyl-2-{4-[2-(tert-butylcarbamoyl)phenyl]-3-hydroxybutyl}benzamide | diarylbutanol deriv. 5
Type:
Small organic molecule
Emp. Form.:
C26H36N2O3
Mol. Mass.:
424.5756
SMILES:
CC(C)(C)NC(=O)c1ccccc1CCC(O)Cc1ccccc1C(=O)NC(C)(C)C
Substrate
Name:
Chromogenic Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
3763.66
Organism:
n/a
Description:
n/a
Residue:
35
Sequence:
HISLYSALAARGVALLEPHEPNGLALANLESERNH