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Target
Programmed cell death 1 ligand 1
Ligand
BDBM649674
Substrate
n/a
Meas. Tech.
Affinity Test Between the Compounds of the Invention and hPD-L1 Protein
Kd
50±n/a nM
Citation
 XU, Y; ZHANG, H; ZHU, Q; DU, H; XIA, Y; YU, C; HUANG, S; LI, H; ZOU, Y NOVEL BIPHENYL DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF US Patent  US20240043392 Publication Date 2/8/2024 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM649674
Synonyms:
N-(2-((4-((3′-(3-(4-(((2-acetylaminoethyl)amino) methyl)-1H-1,2,3-triazole-1-yl)propoxy)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)methoxy)-5-chloro-2-((5-cyanopyridine-3-yl)methoxy) benzyl)amino)ethyl)acetamide | US20240043392, Compound II-3
Type:
Small organic molecule
Emp. Form.:
C43H50ClN9O5
Mol. Mass.:
808.367
SMILES:
CC(=O)NCCNCc1cn(CCCOc2cccc(c2C)-c2cccc(COc3cc(OCc4cncc(c4)C#N)c(CNCCNC(C)=O)cc3Cl)c2C)nn1
Structure:
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