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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM652318
Substrate
n/a
Meas. Tech.
Biochemical QPCT and QPCTL Activity Assay
IC50
3.00±n/a nM
Citation
 WILLWACHER, J; BINDER, FP; DAHMANN, G; YANG HAMILTON, JY; HANDSCHUH, SR; REINDL, SA PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN US Patent  US20240059675 Publication Date 2/22/2024 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM652318
Synonyms:
US20240059675, Example 21
Type:
Small organic molecule
Emp. Form.:
C21H20FN9
Mol. Mass.:
417.4422
SMILES:
Cn1cc2cc(cnc2n1)-c1nccc(C#N)c1N1CCC(F)(CC1)c1nncn1C
Structure:
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