Reaction Details Report a problem with these data
Target
Steroid hormone receptor ERR2
Ligand
BDBM312138
Substrate
n/a
Meas. Tech.
Competitive Radioligand-Binding Assay
Ki
252±n/a nM
Citation
 Narayanan, R; Dalton, JT; Levin, E Nuclear receptor binding agents US Patent  US9604931 Publication Date 3/28/2017 
Target
Name:
Steroid hormone receptor ERR2
Synonyms:
ERR beta-2 | ERR-beta | ERR2_HUMAN | ERRB2 | ESRL2 | ESRRB | Estrogen receptor-like 2 | Estrogen-related receptor beta | NR3B2 | Nuclear receptor subfamily 3 group B member 2 | Steroid hormone receptor ERR2 | Steroid hormone receptor ERR2 Beta
Type:
PROTEIN
Mol. Mass.:
48061.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_11254
Residue:
433
Sequence:
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV
  
Inhibitor
Name:
BDBM312138
Synonyms:
6-hydroxy-2-(4-hydroxyphenol)-4-(4-methoxyphenyl)isoquinolin-1(2H)-one | US9604931, 15b
Type:
Small organic molecule
Emp. Form.:
C22H17NO4
Mol. Mass.:
359.3747
SMILES:
COc1ccc(cc1)-c1cn(-c2ccc(O)cc2)c(=O)c2ccc(O)cc12
Structure:
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