Reaction Details Report a problem with these data
Target
Steroid hormone receptor ERR2
Ligand
BDBM312139
Substrate
n/a
Meas. Tech.
Competitive Radioligand-Binding Assay
Ki
3.96±n/a nM
Citation
 Narayanan, R; Dalton, JT; Levin, E Nuclear receptor binding agents US Patent  US9604931 Publication Date 3/28/2017 
Target
Name:
Steroid hormone receptor ERR2
Synonyms:
ERR beta-2 | ERR-beta | ERR2_HUMAN | ERRB2 | ESRL2 | ESRRB | Estrogen receptor-like 2 | Estrogen-related receptor beta | NR3B2 | Nuclear receptor subfamily 3 group B member 2 | Steroid hormone receptor ERR2 | Steroid hormone receptor ERR2 Beta
Type:
PROTEIN
Mol. Mass.:
48061.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_11254
Residue:
433
Sequence:
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV
  
Inhibitor
Name:
BDBM312139
Synonyms:
2-(3-fluoro-4-hydroxyphenyl)-6,8-dihydroxy-4-vinylisoquinolin-1(2H)-one | US9604931, 15c | US9623021, Compound 15c
Type:
Small organic molecule
Emp. Form.:
C17H12FNO4
Mol. Mass.:
313.2799
SMILES:
Oc1cc(O)c2c(c1)c(C=C)cn(-c1ccc(O)c(F)c1)c2=O
Structure:
Search PDB for entries with ligand similarity: