Reaction Details Report a problem with these data
Target
Nucleoprotein
Ligand
BDBM614527
Substrate
n/a
Meas. Tech.
TBD
EC50
132±n/a nM
Citation
 BARRETT, M; COCKERILL, GS; GOOD, J; AVERY, CA; COCHRANE, EJ; JONES, SP; ONIONS, ST; WARNER, AJ BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION US Patent  US20230270751 Publication Date 8/31/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM614527
Synonyms:
N-[(3S)-2-oxo-5- phenyl-1,3-dihydro- 1,4-benzodiazepin-3- yl]-2-(1-propan-2- ylpyrazol-4-yl)-6,7- dihydro-5H- pyrazolo[5,1- b][1,3]oxazine-3- carboxamide | US20230270751, Example 103
Type:
Small organic molecule
Emp. Form.:
C28H27N7O3
Mol. Mass.:
509.5591
SMILES:
CC(C)n1cc(cn1)-c1nn2CCCOc2c1C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O |t:24|
Structure:
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