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Target
Nucleoprotein
Ligand
BDBM614542
Substrate
n/a
Meas. Tech.
TBD
EC50
53.0±n/a nM
Citation
 BARRETT, M; COCKERILL, GS; GOOD, J; AVERY, CA; COCHRANE, EJ; JONES, SP; ONIONS, ST; WARNER, AJ BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION US Patent  US20230270751 Publication Date 8/31/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM614542
Synonyms:
N-[(3S)-9-fluoro-2- oxo-5-phenyl-1,3- dihydro-1,4- benzodiazepin-3-yl]- 2-(2-fluorophenyl)- 6-(methoxymethyl)- 6,7-dihydro-5H- pyrazolo[5,1- b][1,3]oxazine-3- carboxmaide | US20230270751, Example 113
Type:
Small organic molecule
Emp. Form.:
C30H25F2N5O4
Mol. Mass.:
557.5474
SMILES:
COCC1COc2c(C(=O)N[C@H]3N=C(c4ccccc4)c4cccc(F)c4NC3=O)c(nn2C1)-c1ccccc1F |t:12|
Structure:
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