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Target
Nucleoprotein
Ligand
BDBM614547
Substrate
n/a
Meas. Tech.
TBD
EC50
43.0±n/a nM
Citation
 BARRETT, M; COCKERILL, GS; GOOD, J; AVERY, CA; COCHRANE, EJ; JONES, SP; ONIONS, ST; WARNER, AJ BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION US Patent  US20230270751 Publication Date 8/31/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM614547
Synonyms:
(5R)-N-[(3S)-9- fluoro-2-oxo-5- phenyl-1,3-dihydro- 1,4-benzodiazepin-3- yl]-5-methyl-2-[1- (2,2,2- trifluoroethyl)pyrazol- 4-yl]-6,7-dihydro- 5H-pyrazolo[5,1- b][1,3]oxazine-3- carboxamide | US20230270751, Example 118
Type:
Small organic molecule
Emp. Form.:
C28H23F4N7O3
Mol. Mass.:
581.5209
SMILES:
C[C@@H]1CCn2nc(-c3cnn(CC(F)(F)F)c3)c(C(=O)N[C@H]3N=C(c4ccccc4)c4cccc(F)c4NC3=O)c2O1 |t:23|
Structure:
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