Reaction Details Report a problem with these data
Target
Nucleoprotein
Ligand
BDBM614631
Substrate
n/a
Meas. Tech.
TBD
EC50
280±n/a nM
Citation
 BARRETT, M; COCKERILL, GS; GOOD, J; AVERY, CA; COCHRANE, EJ; JONES, SP; ONIONS, ST; WARNER, AJ BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION US Patent  US20230270751 Publication Date 8/31/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM614631
Synonyms:
(5S*)-N-[(3S)-9- fluoro-2-oxo-5-phenyl- 1,3-dihydro-1,4- benzodiazepin-3-yl]-2- (2-fluorophenyl)-5- (methoxymethyl)-6,7- dihydro-5H- pyrazolo[5,1- b][1,3]oxazine-3- carboxamide | US20230270751, Example 191-2
Type:
Small organic molecule
Emp. Form.:
C30H25F2N5O4
Mol. Mass.:
557.5474
SMILES:
COC[C@@H]1CCn2nc(c(C(=O)N[C@H]3N=C(c4ccccc4)c4cccc(F)c4NC3=O)c2O1)-c1ccccc1F |t:14|
Structure:
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